Pointe Scientific

Overview The fast-paced world of genetic medicine is witnessing rapid advancements, yet the journey towards efficient delivery systems lags behind. The field faces a significant challenge: creating reliable and precise methods to deliver nucleic acid therapeutics such as antisense oligonucleotides (ASOs), short interfering RNA (siRNA),...

Overview Colorectal cancer (CRC) ranks among the top deadly cancers globally. While screening methods have significantly reduced death rates, they do come with their own set of challenges. Colonoscopies, although effective in spotting precancerous polyps, are invasive. This invasiveness often leads individuals to delay or...

Overview Genomics has advanced incredibly since the early days of next-generation sequencing (NGS) in the mid-2000s. Early obstacles, such as the signal-to-noise ratio, have been largely addressed, enabling significant progress in integrating genomics into clinical care. The ability to identify genetic variants accurately has paved...

Overview DNA and RNA-based vaccines have emerged as powerful tools in the fight against infectious diseases. These vaccines use genetic material to instruct cells to produce antigens, which then trigger an immune response. Among these, messenger RNA (mRNA) vaccines have gained significant attention, especially with...

Overview Researchers at the University of Texas MD Anderson Cancer Center have suggested that second-generation antihistamines could be beneficial for patients undergoing immunotherapy. Their data indicates that patients with various types of cancer who were treated with anti-PD-1/PD-L1 checkpoint inhibitors showed improved survival outcomes when...

Overview Recent advancements have introduced a groundbreaking method known as DISCO (digital microfluidic isolation of single cells for –omics). Pioneered by researchers at the University of Toronto, this technique allows for the selection and detailed analysis of individual cells directly from a population on a...

Overview Amber Bio is a burgeoning biotechnology company based in San Francisco. They are making significant strides in the field of RNA editing, focusing on multi-kilobase gene editing platforms that target previously undruggable diseases. Their innovative approach aims to treat conditions arising from various mutations...

Overview Nvelop Therapeutics has stepped into the spotlight as a promising $100-million startup, addressing a critical issue in gene therapy: the effective delivery of genetic medicines. This challenge isn’t new, but Nvelop, armed with substantial seed funding, is tackling it head-on with two innovative, in...

Overview Sequencing and AI Advancements As advances in sequencing technology drive down costs, there is a significant increase in whole genome sequencing (WGS) and whole exome sequencing (WES). Yet, sequencing alone is only the beginning. To harness its full potential, one needs to analyze this...

Overview Multiomics is a cutting-edge field that integrates multiple omics technologies to provide a comprehensive view of biological systems. This includes genomes, transcriptome, and proteome, revealing how organisms respond to various factors like disease, diet, or environmental changes. Central to this approach are powerful next-generation...